International Museum of Surgical Science

Rent a Gold Coast lakefront mansion that also happens to be a museum of surgery.

Why we picked itA Gold Coast mansion that's also a museum of surgery. Delightfully strange.

The museum fills a 12,000-square-foot early-1900s mansion at 1524 N. Lake Shore Drive. Inside are Italian marble floors and fireplaces, walnut walls with historic murals, and floor-to-ceiling views of Lake Michigan.

It books for shoots and events with as little as a one-hour minimum. It holds up to 250 standing or 100 seated, and there's on-site parking for crew trucks.